Nicotiana benthamiana, a scientifically well-studied plant indigenous to Australia, is used as plant host for magnICON®-based protein production. Usually, for all development and manufacturing activities the N. benthamiana wild-type accession “ICON” is used. N. benthamiana “ICON” master and working seed banks were prepared in accordance with the US Food and Drug Administration ”Guidance for Industry: Drugs, Biologics, and Medical Devices Derived from Bioengineered Plants for Use in Humans and Animals” (September 2002). When required, specialized plant hosts developed at Icon Genetics (for example, with human-like glycosylation patterns, improved glycosylation sites occupancy, etc.) are available for production.